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Stress study offers clues for new antidepressant drugs


By Kate Kelland, Reuters
From http://vitals.nbcnews.com/_news/

LONDON - Scientists have worked out the way in which stress hormones reduce the number of new brain cells - a process linked to depression - and say their work should help researchers develop more effective antidepressants. 

The scientists identified a protein largely responsible for the long-term detrimental effect of stress on cells.

They also successfully used an experimental drug compound to block this effect, pointing to a possible way of developing new antidepressants, the study published in the Proceedings of the National Academy of Sciences said.

Major depression affects about 20 percent of people at some time in their lives. The World Health Organization (WHO) predicts that by 2020, depression will rival heart disease as the health disorder with the highest global disease burden.

Treatment for depression involves either medication or counseling - and often a combination of both.

But while there are many antidepressants on the market, including top sellers such as Prozac and Seroxat, it is widely accepted that many antidepressants work in only half of patients half of the time, and drugmakers are struggling to come up with a new generation of drugs.

Depression is linked to changes in a process called neurogenesis - the ability of the adult brain to continue producing new brain cells.

At a molecular level, stress is known to increase levels of a hormone called cortisol, which in turn acts on a receptor called the glucocorticoid receptor. But the exact mechanism behind this process has been unclear.

A team under Carmine Pariante of King's College London's Institute of Psychiatry, who led the research, studied human hippocampal stem cells - source of new cells in the human brain.

They gave the cells cortisol to measure the effect on neurogenesis and found that a protein called SGK1 was important in mediating the effects.

By measuring the effect of cortisol over time, they found that increased levels of SGK1 prolong the damaging impact of stress hormones on neurogenesis.

Next, the researchers used an experimental drug compound known to inhibit SGK1 and found it blocked the negative effects of stress hormones, leading to an increase in new brain cells.

The team confirmed the results by studying levels of SGK1 in animals and then in blood samples from people with depression. 

By Kate Kelland, Reuters
From http://vitals.nbcnews.com/_news/

Is stress making you ill?


Stress management health centre

If you seem to suffer from the common cold a bit too often, perhaps stress is literally making you sick and tired.

By Theresa Bebbington
WebMD Health News
Reviewed by Dr Keith David Barnard
Article from webmd

11th April 2012 - Stress has already been linked to a greater risk of depression, infectious diseases and even heart disease. A recent study has looked at how stress could be causing these health problems.

What is stress?

According to the International Stress Management Association UK, stress is "the adverse reaction people have to excessive pressures or other types of demand placed on them."

When those pressures become overwhelming, they lead to stress. A little stress can be a good thing - it is part of the fight or flight mechanism that allows us to cope with a challenge. However, being in a continual state of stress means that body chemicals used to stimulate the fight or flight response are constantly active, and this can have adverse effects on our mental and physical health.

How stress can make you ill

The research study at Carnegie Mellon University, headed by Dr Sheldon Cohen and published in the Proceedings of the National Academy of Sciences, has for the first time been able to establish that chronic psychological stress affects the body's ability to regulate the inflammatory response, which in turn can allow the development and progression of disease.

"Inflammation is partly regulated by the hormone cortisol, and when cortisol is not allowed to serve this function, inflammation can get out of control," says Dr Cohen, a professor of psychology at Carnegie Mellon University in news release.

The study found that prolonged stress decreases tissue sensitivity to cortisol, so it could alter the effectiveness of cortisol to control the inflammatory response. To be more specific, the immune cells don't response properly to cortisol's regulatory effect, so inflammation isn't controlled. It is this runaway inflammation that allows the development of many diseases.

An earlier study by Dr Cohen showed that psychological stress made people more susceptible to developing the common cold, and he used the common cold virus for testing his theory. The symptoms of common cold are not caused by the virus itself, but are a side-effect of the inflammatory response triggered by the body to fight off the virus. The more your body tries to fight off the infection, the more symptoms of a cold you're likely to experience.

In the first study, 276 healthy adults were exposed to a common cold virus after completing an intensive stress review, and were then put into quarantine for five days. Dr Cohen concluded that in those who suffered a stressful event, the stress affected the immune cells? response to hormonal signals that normally control inflammation. These people were unable to regulate the inflammatory response and were more likely to develop cold symptoms on exposure to the virus.

In his second study, Dr Cohen assessed 79 healthy participants and their inflammatory response before exposing them to a cold virus. He monitored the production of pro-inflammatory cytokines, which are chemical messengers that trigger inflammation. In this study, he found that the participants who were less able to regulate their inflammatory response produced more of these chemical messengers when they were infected.

"The immune system's ability to regulate inflammation predicts who will develop a cold, but more importantly it provides an explanation of how stress can promote disease," says Dr Cohen. "When under stress, cells of the immune system are unable to respond to hormonal control, and consequently, produce levels of inflammation that promote disease. Because inflammation plays a role in many diseases such as cardiovascular, asthma and autoimmune disorders, this model suggests why stress impacts them as well."

He added, "Knowing this is important for identifying which diseases may be influenced by stress and for preventing disease in chronically stressed people."

Is stress making you ill?
If you seem to suffer from the common cold a bit too often, perhaps stress is literally making you sick and tired.(continued)
Symptoms of stress

There are a number of psychological, emotional, physical and behavioural signs to look out for which indicate if someone is under stress:

Psychological signs
  • Inability to concentrate or make simple decisions
  • Memory lapses
  • Becoming rather vague
  • Easily distracted
  • Worrying
  • Negative thinking
  • Depression and anxiety

Emotional signs
  • Being tearful
  • Being irritable
  • Experiencing mood swings
  • Feeling extra sensitive to criticism
  • Being defensive
  • Feeling out of control
  • Lack of motivation
  • Being angry or frustrated
  • Lack of confidence or self-esteem

Behavioural signs
  • No time for relaxation or pleasurable activities
  • Prone to accidents
  • Increased reliance on alcohol, smoking, caffeine, recreation or illegal drugs
  • Becoming a workaholic
  • Poor time management and/or poor standards of work
  • Absenteeism

Physical signs
  • Aches/pains and muscle tension/grinding teeth
  • Frequent colds/infections
  • Allergies/rashes/skin irritations
  • Constipation/diarrhoea/irritable bowel syndrome (IBS)
  • Weight loss or gain
  • Indigestion/heartburn/ulcers
  • Hyperventilating/lump in the throat/pins and needles
  • Dizziness/palpitations
  • Panic attacks/nausea
  • Physical tiredness
  • Menstrual changes/loss of libido/sexual problems
  • Heart problems/high blood pressure
  • Stress takes its toll at the workplace

Work-induced stress is a significant problem in the UK. According to the Health and Safety Executive (HSE), between 2009 and 2010 an estimated 9.8 million working days were lost through work-related stress. For each person experiencing work-related stress, an estimated 22.6 days of work was lost - that is equal to 0.42 days per worker.

Mind, the mental health charity, reports that stress in the workplace is thought to be the second biggest occupational health problem in the UK.

Legally, the Management of Health and Safety at Work Regulations 1999 states that organisations of more than five people are required to assess the risk of stress-related ill health arising from work activities.

Of course, employers should be considering their employees' health, but if that and their legal obligations are not providing enough incentives, perhaps they should also look at the costs to their organisations. Mind reported in June 2011, "British businesses lose an estimated £26 billion each year in sickness absence and lost productivity. With greater awareness and mental health support, they said businesses could save one-third of these costs."


Article from webmd

A neuro-musical evening on stress management


Apr 7, 2012
Article from Deccan Herald

Though each one of us despise stress, if one learns the art of managing stress, every distress can be transformed into Eustress (good stress) which is productive and provides positive results. 


A vocal recital by Dr  Anil Sangli and Sripad S at Jagan Mohan Palace in Mysore. Journalist Ravindra Bhat, Deepa Bhat and Niranjan Bhat are also seen. (pic by special arrangement)
Patience, perseverance, family bondage, mutual support, honesty, compassion, sympathizing for the needy, empathizing with difficulties, leading a proper lifestyle with an emphasis on health matters and above all, listening to good music, goes a long way in alleviating stress. 


This was the gist of the Neuro-Musical program  conducted by Dr  Anil Sangli, consultant neuro and spine surgeon and Sripad S, certified financial planner from Srian Envisions in Jagan Mohan Palace on recently. 

The highlight was the depiction of problems faced by a 10-year old congenitally hearing impaired boy and his family in imparting basic training and guidance to indoctrinate and initiate language processing in the young brain.  A hearing impaired individual becomes a mute due to the fact that he cannot process language which is an important component in thought processes. 

The concepts adopted by mother Deepa Bhat and father journalist Ravindra Bhat, with guidance from the late Wing Cdr Srinivasan to teach the  10-year old chief guest Niranjan Bhat, the various nuances of speech and language, was a motivation and model for parents of many a disabled children. 

The concept and methodology in which the child was made to learn language and speech has been brought out in the book ‘Moorane Kiwi’ meaning ‘The Third Ear’ by  Ravindra Bhat. 

This book has many technicalities in tutoring hearing-impaired individuals, which are not only simple but also innovative. The initial distress of having a hearing-impaired child was metamorphosed to Eustress by patience, perseverance and intellectual handling of the situation.

The programme also brought out various personalities providing insights in the management of strenuous and stressful situations.  

Srian Envisions awarded Dhanalakshmi, presently an outreach worker at Ashakirana Hospital, with the ‘Srian wellness citizen award of the year,’ which carried a cheque and a citation. Gururaj K S, Dr Swami and Narasamma Savita provided inputs in management of concordant and discordant couples afflicted with HIV.

Musical evening

The evening musical programme commenced with a rendition of a bhajan and a duet by Sripad S and Dr Anil Sangli. In between, various scientific inputs and valuable comments by Dr Sangli, melodious songs were rendered by Sripad S, Gayathri S and Dr Snehashree N amidst live orchestra.    

Swami Maheshatmanandaji of RIMSE emphasized on honesty and appropriate communication.  Journalist Krishna Vattam, triumphed on his victory over cancer.  Senior journalist B R Srihari, drew attention to three doctors of his life namely Dr Diet, Dr Quiet and Dr Merryman.  AIR Mysore director M S Vijaya focussed upon overcoming stress in working Indian women.  

Dr Javed Nayeem deplored the rise of suicides in young children and recommended counseling in schoolchildren.   

Rekha Murthy and Dr H V Santhrupth - directors of Gopala Gowda Shantaveri Memorial Hospital, pointed out like-minded wealthy individuals contributing to the less priviliged. 

Anuradha Nandakumar secretary of Mysore District Parents Association Empowerment for Developmentally Disabled, N Narendra - MD of Vinyas IT, Wg Cdr T S Murthy,  Dr Padma Murthy, B R Pai - and others were present.  

The program was a very unique, innovative, novel and unprecedented evening incorporating scientific concepts, music, heart-rendering events to inculcate healthy life styles and habits to transform any sort of stress to bliss.   

Article from Deccan Herald